Gene

mt:ATPase6

Species
Drosophila melanogaster
Symbol
mt:ATPase6
Name
mitochondrial ATPase subunit 6
Synonyms
  • A6
  • ATP6
Biotype
protein coding gene
Automated Description
Predicted to enable proton transmembrane transporter activity. Predicted to contribute to proton-transporting ATP synthase activity, rotational mechanism. Involved in several processes, including determination of adult lifespan; muscle cell cellular homeostasis; and neuron cellular homeostasis. Located in mitochondrion. Is expressed in adult head. Used to study mitochondrial encephalomyopathy and mitochondrial metabolism disease. Human ortholog(s) of this gene implicated in Leber hereditary optic neuropathy; NARP syndrome; Parkinson's disease; multiple sclerosis; and systemic lupus erythematosus. Orthologous to human MT-ATP6 (mitochondrially encoded ATP synthase membrane subunit 6).
FB Description
mitochondrial ATPase subunit 6 (mt:ATPase6) encodes a mitochondrial inner transmembrane protein that is key for oxidative phosphorylation. It couples hydrogen ion transport to ATP synthesis functioning as part of the ATP synthase.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR11410
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
None

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
R6
Viewer Help
4.1k4.2k4.3k4.4k4.5k4.6k4.7k

Sequence Details

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Expression

Primary Sources
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions