Gene

nuf

Species
Drosophila melanogaster
Symbol
nuf
Name
nuclear fallout
Synonyms
  • anon-D2
  • CG32140
Biotype
protein coding gene
Automated Description
Involved in actin cytoskeleton organization; sensory organ precursor cell fate determination; and wing disc dorsal/ventral pattern formation. Located in apical cortex and perinuclear region of cytoplasm. Colocalizes with centrosome. Is expressed in several structures, including anlage in statu nascendi; antennal anlage; antennal primordium; cardiogenic mesoderm; and head epidermis primordium. Orthologous to human RAB11FIP3 (RAB11 family interacting protein 3) and RAB11FIP4 (RAB11 family interacting protein 4).
FB Description
nuclear fallout (nuf) encodes a cytoplasmic, coiled-coil protein that acts as an adaptor between the product of Rab11 and motor proteins in the recycling endosome pathway. It is required for early embryo cellularization, and for subsequent Rab11-dependent processes.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR15726
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
R6
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14.195M14.200M14.205M14.210M14.215M14.220M14.225M14.230M

Sequence Details

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Expression

Primary Sources
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions