Involved in actin cytoskeleton organization; sensory organ precursor cell fate determination; and wing disc dorsal/ventral pattern formation. Located in apical cortex and perinuclear region of cytoplasm. Colocalizes with centrosome. Is expressed in several structures, including anlage in statu nascendi; antennal anlage; antennal primordium; cardiogenic mesoderm; and head epidermis primordium. Orthologous to human RAB11FIP3 (RAB11 family interacting protein 3) and RAB11FIP4 (RAB11 family interacting protein 4).
FB Description
nuclear fallout (nuf) encodes a cytoplasmic, coiled-coil protein that acts as an adaptor between the product of Rab11 and motor proteins in the recycling endosome pathway. It is required for early embryo cellularization, and for subsequent Rab11-dependent processes.