Gene

Fkbp12

Species
Drosophila melanogaster
Symbol
Fkbp12
Name
FK506-binding protein 12kD
Synonyms
  • 11001
  • 143729_at
Biotype
protein coding gene
Automated Description
Enables type I transforming growth factor beta receptor binding activity. Located in plasma membrane. Is expressed in several structures, including adult head; female germline cell; ganglia; gut section; and somatic muscle cell. Human ortholog(s) of this gene implicated in Graves' disease. Orthologous to several human genes including FKBP1A (FKBP prolyl isomerase 1A).
FB Description
FK506-binding protein 12kD (Fkbp12) encodes a protein that binds the intracellular calcium channel encoded by RyR in an oxidation dependent manner. Loss of the binding between the products of Fkbp12 and RyR results in increased calcium leak and reduced muscle function.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR10516
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

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    Disease Associations

    Cases where the expected disease association was NOT found
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    Alleles and Variants

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      Transgenic Alleles

      Species
      (carrying the transgene)
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        Models

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          Sequence Feature Viewer

          Genome location
          Assembly version
          R6
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          Sequence Details

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          Expression

          Primary Sources
          Other Sources
          Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

          Molecular Interactions

          Fkbp12 molecule type
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            Genetic Interactions

            Fkbp12 role
            Fkbp12 genetic perturbation
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