Version: 8.0.0
Date: Tue Jan 28 2025
nAChRα3
Drosophila melanogasterFB:FBgn0015519
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

nAChRα3

Species
Drosophila melanogaster
Symbol
nAChRα3
Name
nicotinic Acetylcholine Receptor alpha3
Synonyms
  • Acr7E
  • alpha3
Biotype
protein coding gene
Automated Description
Contributes to acetylcholine receptor activity and acetylcholine-gated monoatomic cation-selective channel activity. Involved in monoatomic cation transport. Part of acetylcholine-gated channel complex. Is expressed in adult head and lamina monopolar neuron L2. Human ortholog(s) of this gene implicated in several diseases, including alcohol dependence; autosomal dominant nocturnal frontal lobe epilepsy (multiple); congenital myasthenic syndrome (multiple); gastrointestinal system cancer (multiple); and lung cancer (multiple). Orthologous to several human genes including CHRNA3 (cholinergic receptor nicotinic alpha 3 subunit) and CHRNA6 (cholinergic receptor nicotinic alpha 6 subunit).
FB Description
nicotinic Acetylcholine Receptor alpha3 (nAChRalpha3) encodes a subunit of the nicotinic acetylcholine receptor, which is a pentameric neurotransmitter-gated ion channel.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR18945
No data available
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
Phenotype Term
Annotation details
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    Disease Associations

    Cases where the expected disease association was NOT found
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    Gene
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      Alleles and Variants

      Allele/Variant Symbol
      Allele Synonyms
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      Variant type
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        Transgenic Alleles

        Species
        (carrying the transgene)
        Allele symbol
        Transgenic construct
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        Knock-down targets
        Regulatory regions
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          Models

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            Sequence Feature Viewer

            Genome location
            Assembly version
            R6
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            Data currently unavailable; sequence viewer under construction

            Sequence Details

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            Expression

            Primary Sources
            Other Sources
            Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

            Molecular Interactions

            nAChRα3 molecule type
            Interactor gene
            Interactor species
            Interactor molecule type
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              Genetic Interactions

              nAChRα3 role
              nAChRα3 genetic perturbation
              Interactor gene
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              Interactor genetic perturbation
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