Predicted to enable ATP hydrolysis activity and mismatched DNA binding activity. Involved in interstrand cross-link repair; maintenance of DNA repeat elements; and mismatch repair. Predicted to be part of MutSalpha complex. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in several diseases, including Lynch syndrome (multiple); gastrointestinal system cancer (multiple); lung cancer (multiple); mismatch repair cancer syndrome; and transitional cell carcinoma. Orthologous to human MSH2 (mutS homolog 2).