Gene

Nak

Species
Drosophila melanogaster
Symbol
Nak
Name
Numb-associated kinase
Synonyms
  • CG10637
  • nak
Biotype
protein coding gene
Automated Description
Enables AP-2 adaptor complex binding activity and PTB domain binding activity. Involved in several processes, including dendrite morphogenesis; positive regulation of Notch signaling pathway; and regulation of clathrin-dependent endocytosis. Located in axon; dendrite; and neuronal cell body. Is expressed in several structures, including anlage in statu nascendi; central brain anlage in statu nascendi; embryonic/larval midgut; gland; and nephrocyte. Orthologous to several human genes including AAK1 (AP2 associated kinase 1).
FB Description
Numb-associated kinase (Nak) encodes an Ark family member that regulates the product of numb function. It contributes to dendrite development by regulating clathrin localization.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR22967
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Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

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    Disease Associations

    Cases where the expected disease association was NOT found
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    Alleles and Variants

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      Transgenic Alleles

      Species
      (carrying the transgene)
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        Models

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          Sequence Feature Viewer

          Genome location
          Assembly version
          R6
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          Sequence Details

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          Expression

          Primary Sources
          Other Sources
          Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

          Molecular Interactions

          Nak molecule type
          Interactor gene
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            Genetic Interactions

            Nak role
            Nak genetic perturbation
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