Predicted to enable iron-sulfur cluster binding activity. Predicted to contribute to NADH dehydrogenase (ubiquinone) activity. Predicted to be involved in cellular respiration; mitochondrial respiratory chain complex I assembly; and reactive oxygen species metabolic process. Part of respiratory chain complex I. Is expressed in several structures, including adult head; adult heart; dorsal pharyngeal muscle cell; embryonic/larval midgut primordium; and ganglia. Used to study mitochondrial metabolism disease and nuclear type mitochondrial complex I deficiency 5. Human ortholog(s) of this gene implicated in inherited metabolic disorder; mitochondrial complex I deficiency; and nuclear type mitochondrial complex I deficiency 5. Orthologous to human NDUFS1 (NADH:ubiquinone oxidoreductase core subunit S1).