Version: 8.0.0
Date: Tue Jan 28 2025
ppk
Drosophila melanogasterFB:FBgn0020258
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

ppk

Species
Drosophila melanogaster
Symbol
ppk
Name
pickpocket
Synonyms
  • BG:DS06238.1
  • CG3478
Biotype
protein coding gene
Automated Description
Enables pH-gated monoatomic ion channel activity. Involved in several processes, including detection of stimulus involved in sensory perception of pain; mechanosensory behavior; and negative regulation of feeding behavior. Located in dendrite membrane. Part of monoatomic ion channel complex. Is expressed in several structures, including adult sex peptide sensory neurons; appendage; multidendritic neurons; neuron projection bundle; and sensory nervous system primordium. Orthologous to several human genes including ASIC1 (acid sensing ion channel subunit 1); ASIC2 (acid sensing ion channel subunit 2); and ASIC3 (acid sensing ion channel subunit 3).
FB Description
pickpocket (ppk) encodes an acid-sensing sodium channel from the degenerin/epithelial sodium channel (DEG/ENaC) family. It contributes to mechanical nociception, larval behavior and dendrite morphogenesis.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR11690
No data available
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
Phenotype Term
Annotation details
References
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume
    Gene
    Association
    Disease Qualifier
    Disease
    Evidence
    Source
    Based On
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      Alleles and Variants

      Allele/Variant Symbol
      Allele Synonyms
      Category
      Variant
      Variant type
      Molecular consequence
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        Transgenic Alleles

        Species
        (carrying the transgene)
        Allele symbol
        Transgenic construct
        Expressed components
        Knock-down targets
        Regulatory regions
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          Models

          Model name
          Experimental condition
          Associated Human Diseases
          Associated Phenotypes
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            Sequence Feature Viewer

            Genome location
            Assembly version
            R6
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            14.3785M14.3790M14.3795M14.3800M14.3805M14.3810M

            Sequence Details

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            Expression

            Primary Sources
            Other Sources
            Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

            Molecular Interactions

            ppk molecule type
            Interactor gene
            Interactor species
            Interactor molecule type
            Detection methods
            Source
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              Genetic Interactions

              ppk role
              ppk genetic perturbation
              Interactor gene
              Interactor species
              Interactor role
              Interactor genetic perturbation
              Interaction type
              Phenotype or trait
              Source
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