Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including copper ion import; imaginal disc-derived appendage morphogenesis; and midgut development. Located in cytosol and nucleus. Is expressed in several structures, including embryonic/larval midgut cell; ganglia; gut section; head epidermis primordium; and imaginal disc. Human ortholog(s) of this gene implicated in SATB2-associated syndrome. Orthologous to human SATB1 (SATB homeobox 1) and SATB2 (SATB homeobox 2).
FB Description
defective proventriculus (dve) encodes a transcriptional repressor that binds to the K50 site. It is involved in developmental patterning, cell-type specification, and functional differentiation.