Version: 8.0.0
Date: Tue Jan 28 2025
Nrk
Drosophila melanogasterFB:FBgn0020391
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

Nrk

Species
Drosophila melanogaster
Symbol
Nrk
Name
Neurospecific receptor kinase
Synonyms
  • anon-WO2004063362.79
  • CG4007
Biotype
protein coding gene
Automated Description
Enables protein tyrosine kinase activity. Involved in muscle cell cellular homeostasis; neuron development; and signal transduction. Predicted to be part of receptor complex. Predicted to be active in plasma membrane. Is expressed in neurogenic region; peripheral nervous system; and presumptive embryonic/larval central nervous system. Human ortholog(s) of this gene implicated in congenital myasthenic syndrome 9 and fetal akinesia deformation sequence syndrome 1. Orthologous to human MUSK (muscle associated receptor tyrosine kinase).
FB Description
Neurospecific receptor kinase (Nrk) encodes a receptor tyrosine kinase that is expressed in the developing nervous system and regulates axon pathfinding and rhabdomere elongation. It interacts genetically with Dys and Dg.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR24416
No data available
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Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
Phenotype Term
Annotation details
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume
    Gene
    Association
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    Disease
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      Alleles and Variants

      Allele/Variant Symbol
      Allele Synonyms
      Category
      Variant
      Variant type
      Molecular consequence
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        Transgenic Alleles

        Species
        (carrying the transgene)
        Allele symbol
        Transgenic construct
        Expressed components
        Knock-down targets
        Regulatory regions
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          Models

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            Sequence Feature Viewer

            Genome location
            Assembly version
            R6
            Viewer Help
            13.1605M13.1610M13.1615M13.1620M13.1625M13.1630M

            Sequence Details

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            Expression

            Primary Sources
            Other Sources
            Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

            Molecular Interactions

            Nrk molecule type
            Interactor gene
            Interactor species
            Interactor molecule type
            Detection methods
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              Genetic Interactions

              Nrk role
              Nrk genetic perturbation
              Interactor gene
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              Interactor role
              Interactor genetic perturbation
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              Phenotype or trait
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