Gene

Paics

Species
Drosophila melanogaster
Symbol
Paics
Name
PAICS bifunctional enzyme
Synonyms
  • ade5
  • Ade5
Biotype
protein coding gene
Automated Description
Enables phosphoribosylaminoimidazolesuccinocarboxamide synthase activity. Involved in 'de novo' IMP biosynthetic process. Located in cytosol. Is expressed in several structures, including adult brain cell body rind; embryonic/larval midgut primordium; epithelium; female germline cell; and somatic trunk mesoderm derivative. Human ortholog(s) of this gene implicated in schizophrenia. Orthologous to human PAICS (phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazolesuccinocarboxamide synthase).
FB Description
PAICS bifunctional enzyme (Paics) encodes an essential enzyme in the pathway for de novo synthesis of the purine nucleotide inosine monophosphate (IMP). IMP is the precursor for purine nucleotides required for nucleic acids, energy transfer, cell signaling, and coenzymes.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR43599
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
R6
Viewer Help
12.7575M12.7580M12.7585M12.7590M12.7595M12.7600M12.7605M

Sequence Details

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Expression

Primary Sources
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions