Enables phosphoribosylaminoimidazolesuccinocarboxamide synthase activity. Involved in 'de novo' IMP biosynthetic process. Located in cytosol. Is expressed in several structures, including adult brain cell body rind; embryonic/larval midgut primordium; epithelium; female germline cell; and somatic trunk mesoderm derivative. Human ortholog(s) of this gene implicated in schizophrenia. Orthologous to human PAICS (phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazolesuccinocarboxamide synthase).
FB Description
PAICS bifunctional enzyme (Paics) encodes an essential enzyme in the pathway for de novo synthesis of the purine nucleotide inosine monophosphate (IMP). IMP is the precursor for purine nucleotides required for nucleic acids, energy transfer, cell signaling, and coenzymes.