Gene

Coprox

Species
Drosophila melanogaster
Symbol
Coprox
Name
Coproporphyrinogen oxidase
Synonyms
  • BcDNA:GM14838
  • CG3433
Biotype
protein coding gene
Automated Description
Predicted to enable coproporphyrinogen oxidase activity and protein homodimerization activity. Predicted to be involved in protoporphyrinogen IX biosynthetic process. Predicted to be located in mitochondrion. Predicted to be active in cytoplasm. Is expressed in adult head; anterior midgut primordium; embryonic/larval midgut; organism; and posterior midgut primordium. Human ortholog(s) of this gene implicated in hereditary coproporphyria and liver disease. Orthologous to human CPOX (coproporphyrinogen oxidase).
FB Description
Not Available
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR10755
Stringency:
Additional filters to further constrain the results:
Species Gene symbol Count Best Best reverse
Method
Ensembl ComparaHGNCHieranoidInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidXenbaseZFIN
Homo sapiensCPOX8 of 9YesYes   
Mus musculusCpox8 of 9YesYes   
Rattus norvegicusCpox8 of 9YesYes   
Xenopus tropicaliscpox8 of 9YesYes   
Danio reriocpox8 of 10YesYes  
Saccharomyces cerevisiaeHEM139 of 9YesYes   
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

No paralogs for the gene.

Function - GO Annotations

No function available for that gene

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
Phenotype Term
Annotation details
References
lethal | recessive
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Disease Associations

Cases where the expected disease association was NOT found
Must provide at least one subject
Cell color indicative of annotation volume

Alleles and Variants

Genome location
Assembly version
R6
Viewer Help
6.9646M6.9648M6.9650M6.9652M6.9654M6.9656M6.9658M
Variant Types and ConsequencesOnly variants associated to alleles are shown in the graphics above. See all variants in JBrowse.
Allele/Variant Symbol
Allele Synonyms
Category
Variant
Variant type
Molecular consequence
Has Disease Annotations
Has Phenotype Annotations
Coproxk10602b
  • Coprox[k10602b]
  • l(2)k10617[k10602b]
allele
Yes
CoproxSK4
  • CG3433[SK4]
  • CG3433SK4
allele with one associated variant
deletion
  • frameshift variant
Coproxk10617
  • Coprox[k10617]
  • l(2)k10617
allele with one associated variant
insertion
  • 5 prime UTR variant
Yes
CoproxCB-5151-3
  • Coprox[CB-5151-3]
allele with one associated variant
insertion
  • coding sequence variant
Coproxe02019
  • Coprox[e02019]
allele with one associated variant
insertion
  • 3 prime UTR variant
CoproxEY08423
  • Coprox[EY08423]
allele with one associated variant
insertion
  • 5 prime UTR variant
Coproxk11018
  • Coprox[k11018]
  • l(2)k11018
allele with one associated variant
insertion
  • 5 prime UTR variant
Yes
NT_033779.5:g.6964938G>Avariant
SNP
  • synonymous variant
NT_033779.5:g.6965405G>Avariant
SNP
  • missense variant
NT_033779.5:g.6965613G>Avariant
SNP
  • synonymous variant
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Transgenic Alleles

Species
(carrying the transgene)
Allele symbol
Transgenic construct
Expressed components
Knock-down targets
Regulatory regions
Has Disease Annotations
Has Phenotype Annotations
Drosophila melanogasterCoproxGD5344
  • UASt
Drosophila melanogasterCoproxHMC04005
  • UAS
Drosophila melanogasterCoproxKK101688
  • UASt
Drosophila melanogasterCoproxNIG.3433R
  • UASt
Drosophila melanogasterCoproxTOE.GS00521
Drosophila melanogasterCoproxU6.NIG.sgRNA
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Models

No data available

Sequence Feature Viewer

Genome location
Assembly version
R6
Viewer Help
6.9646M6.9648M6.9650M6.9652M6.9654M6.9656M6.9658MCoprox-RA (Coprox)Coprox-RB (Coprox)

Sequence Details

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Expression

Primary Sources
Other Sources
Must provide at least one subject
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

8 interactor genes based on 8 annotations
Coprox molecule type
Interactor gene
Interactor species
Interactor molecule type
Detection methods
Source
Reference
protein
Diap2Drosophila melanogaster
protein
  • experimental knowledge based
PMID:22036573
protein
dlDrosophila melanogaster
protein
  • two hybrid
PMID:14605208
protein
mtDNA-helicaseDrosophila melanogaster
protein
  • experimental knowledge based
PMID:22036573
protein
Myo10ADrosophila melanogaster
protein
  • two hybrid
PMID:14605208
protein
p53Drosophila melanogaster
protein
  • pull down
PMID:20308539
protein
Prx4Drosophila melanogaster
protein
  • experimental knowledge based
PMID:22036573
protein
Tom20Drosophila melanogaster
protein
  • proximity labelling technology
PMID:36762624
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Genetic Interactions

Coprox role
Coprox genetic perturbation
Interactor gene
Interactor species
Interactor role
Interactor genetic perturbation
Interaction type
Phenotype or trait
Source
Reference
suppressor gene
pebDrosophila melanogaster
suppressed gene
genetic suppression
    PMID:15454543
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