Gene

CycH

Species
Drosophila melanogaster
Symbol
CycH
Name
Cyclin H
Synonyms
  • 142767_at
  • CCNH
Biotype
protein coding gene
Automated Description
Enables cyclin-dependent protein serine/threonine kinase regulator activity. Involved in transcription by RNA polymerase II. Part of transcription factor TFIIH holo complex. Orthologous to human CCNH (cyclin H).
FB Description
Not Available
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR10026
Stringency:
Additional filters to further constrain the results:
Species Gene symbol Count Best Best reverse
Method
Ensembl ComparaHGNCHieranoidInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidXenbaseZFIN
Homo sapiensCCNH9 of 9YesYes   
Mus musculusCcnh9 of 9YesYes   
Rattus norvegicusCcnh9 of 9YesYes   
Xenopus tropicalisccnh4 of 9YesYes   
Danio rerioccnh8 of 10YesYes  
Saccharomyces cerevisiaeCCL17 of 9YesYes   
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Gene symbolRank Alignment Length (aa) Similarity %Identity %Method Count
Method
Ensembl ComparaHGNCInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidSGD
CG16903133340203 of 8  
CycC229441243 of 8  
CycT333034193 of 8  
CycK423441213 of 8  
koko524140203 of 8  

Function - GO Annotations

No function available for that gene

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
No data available

Disease Associations

Cases where the expected disease association was NOT found
all annotationsall disease by infectious agentbacterial infectious diseasefungal infectious diseaseparasitic infectious diseaseviral infectious diseaseall disease of anatomical entitycardiovascular system diseasecentral nervous system diseaseendocrine system diseasegastrointestinal system diseasehematopoietic system diseaseimmune system diseaseintegumentary system diseasemusculoskeletal system diseaseperipheral nervous system diseasereproductive system diseaserespiratory system diseasesensory system diseasethoracic diseaseurinary system diseaseall disease of cellular proliferationbenign neoplasmcancerpre-malignant neoplasmall genetic diseasechromosomal diseasemonogenic diseasepolygenic diseaseall other diseasedisease of mental healthdisease of metabolismphysical disordersyndrome
CycH (Dme)
CCNH (Hsa)
Ccnh (Mmu)
Ccnh (Rno)
ccnh (Xtr)
ccnh (Dre)
CCL1 (Sce)
Cell color indicative of annotation volume
Species
Gene
Association
Disease Qualifier
Disease
Evidence
Source
Based On
References
Rattus norvegicusCcnh
is marker fortransient cerebral ischemia
  • IEP
    Showing 1 - 1 of 1 rows
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    Alleles and Variants

    Genome location
    Assembly version
    R6
    Viewer Help
    21.8220M21.8222M21.8224M21.8226M21.8228M21.8230M21.8232MCycH<GS9043>CycH<KG02273>CycHCycH-RA
    Variant Types and ConsequencesOnly variants associated to alleles are shown in the graphics above. See all variants in JBrowse.
    Allele/Variant Symbol
    Allele Synonyms
    Category
    Variant
    Variant type
    Molecular consequence
    Has Disease Annotations
    Has Phenotype Annotations
    CycHKG02273
    • CycH[KG02273]
    allele with one associated variant
    insertion
    • coding sequence variant
    CycHEP3658
    • CycH[EP3658]
    • EP3658
    allele with one associated variant
    CycHGS9043
    • CycH[GS9043]
    allele with one associated variant
    NT_037436.4:g.21822909G>Tvariant
    SNP
    • intron variant
    NT_037436.4:g.21822892T>Gvariant
    SNP
    • splice region variant
    NT_037436.4:g.21822137T>Avariant
    SNP
    • missense variant
    NT_037436.4:g.21822459A>Gvariant
    SNP
    • synonymous variant
    NT_037436.4:g.21822167C>Avariant
    SNP
    • synonymous variant
    NT_037436.4:g.21822345A>Cvariant
    SNP
    • intron variant
    NT_037436.4:g.21822918C>Tvariant
    SNP
    • intron variant
    Showing 1 - 10 of 21 rows
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    Transgenic Alleles

    Species
    (carrying the transgene)
    Allele symbol
    Transgenic construct
    Expressed components
    Knock-down targets
    Regulatory regions
    Has Disease Annotations
    Has Phenotype Annotations
    Drosophila melanogasterCycHGD4137
    • UASt
    Drosophila melanogasterCycHHD_CFD01587
    • UAS
    Drosophila melanogasterCycHHMS01212
    • UAS
    Drosophila melanogasterCycHKK107336
    • UASt
    Drosophila melanogasterCycHNIG.7405R
    • UASt
    Drosophila melanogasterCycHTOE.GS02199
    Drosophila melanogasterCycHUAS.ORF.GW.Tag:HA
    • UASt
    Drosophila melanogasterCycHUAS.cNa
    • UASt
    Showing 1 - 8 of 8 rows
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    Models

    No data available

    Sequence Feature Viewer

    Genome location
    Assembly version
    R6
    Viewer Help
    21.8220M21.8222M21.8224M21.8226M21.8228M21.8230M21.8232MCycH-RA (CycH)

    Sequence Details

    Loading...

    Expression

    Primary Sources
    Other Sources
    all annotationsall anatomical structuresalimentary part of gastrointestinal systemchemosensory systemcirculatory systemendocrine systemexocrine systemhemolymphoid systemhepatobiliary systemintegumental systemmechanosensory systemmusculoskeletal systemnervous systemrenal systemreproductive systemrespiratory systemsensory systemvestibulo-auditory systemvisual systemendodermectodermmesodermmesenchymeadipose tissueappendageentire extraembryonic componentimaginal precursorpharyngeal archotherall stagesembryo stagepost embryonic, pre-adultpost-juvenile adult stageall cellular componentsextracellular regionplasma membranesynapsecell junctioncell projectioncytoplasmic vesicleendosomevacuolegolgi apparatusendoplasmic reticulumcytosolmitochondrionnucleuschromosomecytoskeletonprotein-containing complexother locations
    CycH (Dme)
    Ccnh (Mmu)
    ccnh (Dre)
    CCL1 (Sce)
    Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

    Molecular Interactions

    34 interactor genes based on 37 annotations
    CycH molecule type
    Interactor gene
    Interactor species
    Interactor molecule type
    Detection methods
    Source
    Reference
    protein
    Cdk1Drosophila melanogaster
    protein
    • two hybrid
    PMID:15575970
    protein
    Cdk2Drosophila melanogaster
    protein
    • two hybrid
    PMID:15575970
    protein
    Cdk4Drosophila melanogaster
    protein
    • two hybrid
    PMID:15575970
    protein
    Cdk4Drosophila melanogaster
    protein
    • two hybrid
    PMID:15575970
    protein
    Cdk7Drosophila melanogaster
    protein
    • experimental knowledge based
    PMID:22036573
    protein
    Cdk7Drosophila melanogaster
    protein
    • anti tag coimmunoprecipitation
    PMID:25242320
    protein
    CenG1ADrosophila melanogaster
    protein
    • two hybrid
    PMID:15575970
    protein
    CG5568Drosophila melanogaster
    protein
    • two hybrid
    PMID:15575970
    protein
    CG5708Drosophila melanogaster
    protein
    • two hybrid
    PMID:15575970
    protein
    CG5731Drosophila melanogaster
    protein
    • two hybrid
    PMID:15575970
    Showing 1 - 10 of 34 rows
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    Genetic Interactions

    CycH role
    CycH genetic perturbation
    Interactor gene
    Interactor species
    Interactor role
    Interactor genetic perturbation
    Interaction type
    Phenotype or trait
    Source
    Reference
    enhancer gene
    pblDrosophila melanogaster
    enhanced gene
    genetic enhancement
      PMID:18690061
      suppressor gene
      pblDrosophila melanogaster
      suppressed gene
      genetic suppression
        PMID:18690061
        enhancer gene
        shtdDrosophila melanogaster
        enhanced gene
        genetic enhancement
          PMID:17689521
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