Gene

melt

Species
Drosophila melanogaster
Symbol
melt
Name
melted
Synonyms
  • 1441/14
  • anon-WO03014152.10
Biotype
protein coding gene
Automated Description
Enables molecular sequestering activity and phosphatidylinositol-5-phosphate binding activity. Involved in R8 cell fate specification; cellular response to starvation; and positive regulation of signal transduction. Located in plasma membrane. Is expressed in several structures, including ectoderm; ganglia; photoreceptor cell R8 of pale ommatidium; ventral furrow; and ventral nerve cord primordium. Orthologous to human VEPH1 (ventricular zone expressed PH domain containing 1).
FB Description
melted (melt) encodes an evolutionarily conserved modulator of the insulin/PI3K signaling pathway. It also plays a post-mitotic role in R8 photoreceptor cells in the bistable choice of rhodopsin expression.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR21630
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
R6
Viewer Help
7.135M7.136M7.137M7.138M7.139M7.140M7.141M7.142M7.143M

Sequence Details

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Expression

Primary Sources
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions