Enables molecular sequestering activity and phosphatidylinositol-5-phosphate binding activity. Involved in R8 cell fate specification; cellular response to starvation; and positive regulation of signal transduction. Located in plasma membrane. Is expressed in several structures, including ectoderm; ganglia; photoreceptor cell R8 of pale ommatidium; ventral furrow; and ventral nerve cord primordium. Orthologous to human VEPH1 (ventricular zone expressed PH domain containing 1).
FB Description
melted (melt) encodes an evolutionarily conserved modulator of the insulin/PI3K signaling pathway. It also plays a post-mitotic role in R8 photoreceptor cells in the bistable choice of rhodopsin expression.