Enables several functions, including core promoter sequence-specific DNA binding activity; histone H3K4 methyltransferase activity; and transcription coactivator activity. Involved in several processes, including positive regulation of ecdysone receptor signaling pathway; progression of morphogenetic furrow involved in compound eye morphogenesis; and response to ecdysone. Located in nucleus and polytene chromosome puff. Part of MLL3/4 complex. Is expressed in several structures, including embryonic/larval salivary gland; female germline cell; ganglia; gut section; and mesoderm. Used to study Kleefstra syndrome 2 and congenital heart disease. Human ortholog(s) of this gene implicated in Kabuki syndrome; Kleefstra syndrome 2; carcinoma (multiple); intracranial aneurysm; and stomach cancer (multiple). Orthologous to several human genes including KMT2D (lysine methyltransferase 2D).
FB Description
trithorax-related (trr) encodes a methyltransferase that trimethylates lysine 4 of the histone encoded by His3. The activity of the product of trr is stimulated by ecdysone and is important for eye development.