Gene

trr

Species
Drosophila melanogaster
Symbol
trr
Name
trithorax-related
Synonyms
  • anon-2Bb
  • CG3848
Biotype
protein coding gene
Automated Description
Enables several functions, including core promoter sequence-specific DNA binding activity; histone H3K4 methyltransferase activity; and transcription coactivator activity. Involved in several processes, including positive regulation of ecdysone receptor signaling pathway; progression of morphogenetic furrow involved in compound eye morphogenesis; and response to ecdysone. Located in nucleus and polytene chromosome puff. Part of MLL3/4 complex. Is expressed in several structures, including embryonic/larval salivary gland; female germline cell; ganglia; gut section; and mesoderm. Used to study Kleefstra syndrome 2 and congenital heart disease. Human ortholog(s) of this gene implicated in Kabuki syndrome; Kleefstra syndrome 2; carcinoma (multiple); intracranial aneurysm; and stomach cancer (multiple). Orthologous to several human genes including KMT2D (lysine methyltransferase 2D).
FB Description
trithorax-related (trr) encodes a methyltransferase that trimethylates lysine 4 of the histone encoded by His3. The activity of the product of trr is stimulated by ecdysone and is important for eye development.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR45888
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
R6
Viewer Help
1.882M1.883M1.884M1.885M1.886M1.887M1.888M1.889M

Sequence Details

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Expression

Primary Sources
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions