Version: 8.0.0
Date: Tue Jan 28 2025
WASp
Drosophila melanogasterFB:FBgn0024273
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

WASp

Species
Drosophila melanogaster
Symbol
WASp
Name
WASp
Synonyms
  • CG1520
  • D-WASP
Biotype
protein coding gene
Automated Description
Predicted to enable small GTPase binding activity. Involved in several processes, including axon development; cytoskeleton organization; and epithelial cell differentiation. Located in several cellular components, including microvillus; neuromuscular junction; and rhabdomere. Part of protein-containing complex. Is expressed in several structures, including adult head; embryonic salivary gland duct; embryonic ventral epidermis; embryonic/larval neuromuscular junction; and epithelium. Human ortholog(s) of this gene implicated in Wiskott-Aldrich syndrome; X-linked severe congenital neutropenia; and thrombocytopenia. Orthologous to several human genes including WAS (WASP actin nucleation promoting factor).
FB Description
WASp (WASp) encodes the homolog of the conserved Wiskott-Aldrich Syndrome family of nucleation promoting factors. It enables the Arp2/3 complex to nucleate polymerization of branched microfilament arrays. It contributes to gastrulation, myoblast fusion, synapse morphology at neuromuscular junctions, sensory organ development, and spermatogenesis.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR23202
No data available
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
Phenotype Term
Annotation details
References
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume
    Gene
    Association
    Disease Qualifier
    Disease
    Evidence
    Source
    Based On
    References
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      Alleles and Variants

      Allele/Variant Symbol
      Allele Synonyms
      Category
      Variant
      Variant type
      Molecular consequence
      Has Disease Annotations
      Has Phenotype Annotations
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        Transgenic Alleles

        Species
        (carrying the transgene)
        Allele symbol
        Transgenic construct
        Expressed components
        Knock-down targets
        Regulatory regions
        Has Disease Annotations
        Has Phenotype Annotations
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          Models

          Model name
          Experimental condition
          Associated Human Diseases
          Associated Phenotypes
          Modifier
          Source
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            Sequence Feature Viewer

            Genome location
            Assembly version
            R6
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            28.825M28.826M28.827M28.828M28.829M28.830M28.831M28.832M

            Sequence Details

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            Expression

            Primary Sources
            Other Sources
            Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

            Molecular Interactions

            WASp molecule type
            Interactor gene
            Interactor species
            Interactor molecule type
            Detection methods
            Source
            Reference
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              Genetic Interactions

              WASp role
              WASp genetic perturbation
              Interactor gene
              Interactor species
              Interactor role
              Interactor genetic perturbation
              Interaction type
              Phenotype or trait
              Source
              Reference
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