Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in male gonad development. Predicted to be active in nucleus. Is expressed in several structures, including Malpighian tubule primordium; anal pad primordium; embryonic anal pad; gonad; and somatic cell of ovariole. Human ortholog(s) of this gene implicated in Kallmann syndrome; PCWH syndrome; Waardenburg syndrome (multiple); campomelic dysplasia; and lung cancer (multiple). Orthologous to several human genes including SOX10 (SRY-box transcription factor 10) and SOX9 (SRY-box transcription factor 9).
FB Description
Sox100B (Sox100B) encodes a group E Sox domain transcription factor. It has a role in the development of somatic components of the testis during metamorphosis, where it regulates pigment cell specification. Sox100B shows sexually dimorphic expression in the embryonic gonad.