Involved in establishment of endothelial barrier; glial cell migration; and smooth septate junction assembly. Located in apicolateral plasma membrane and smooth septate junction. Is expressed in several structures, including embryonic/larval hemocyte; epithelium; ganglia; gut section; and somatic precursor cell. Human ortholog(s) of this gene implicated in retinitis pigmentosa 7. Orthologous to human ROM1 (retinal outer segment membrane protein 1); TSPAN10 (tetraspanin 10); and TSPAN32 (tetraspanin 32).