Version: 8.0.0
Date: Tue Jan 28 2025
E2f2
Drosophila melanogasterFB:FBgn0024371
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

E2f2

Species
Drosophila melanogaster
Symbol
E2f2
Name
E2F transcription factor 2
Synonyms
  • CG1071
  • dE2F-2
Biotype
protein coding gene
Automated Description
Enables RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Contributes to DNA-binding transcription repressor activity, RNA polymerase II-specific. Involved in several processes, including DNA endoreduplication; negative regulation of G1/S transition of mitotic cell cycle; and negative regulation of nucleobase-containing compound metabolic process. Located in chromatin. Part of DRM complex; Myb complex; and Rb-E2F complex. Is active in nucleus. Is expressed in several structures, including Malpighian tubule primordium; anterior endoderm; embryonic/larval midgut primordium; ganglia; and gut section. Human ortholog(s) of this gene implicated in prostate carcinoma. Orthologous to human E2F5 (E2F transcription factor 5).
FB Description
E2F transcription factor 2 (E2f2) encodes a transcription factor that belongs to the E2F gene family. It is a subunit of the DREAM complex, where it forms a heterodimer with the product of Dp to bind to DNA and repress transcription. Among their trancription targets are cell cycle genes and differentiation related genes.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR12081
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Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
Phenotype Term
Annotation details
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume
    No data available

    Alleles and Variants

    Allele/Variant Symbol
    Allele Synonyms
    Category
    Variant
    Variant type
    Molecular consequence
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      Transgenic Alleles

      Species
      (carrying the transgene)
      Allele symbol
      Transgenic construct
      Expressed components
      Knock-down targets
      Regulatory regions
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        Models

        Model name
        Experimental condition
        Associated Human Diseases
        Associated Phenotypes
        Modifier
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          Sequence Feature Viewer

          Genome location
          Assembly version
          R6
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          Data currently unavailable; sequence viewer under construction

          Sequence Details

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          Expression

          Primary Sources
          Other Sources
          Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

          Molecular Interactions

          E2f2 molecule type
          Interactor gene
          Interactor species
          Interactor molecule type
          Detection methods
          Source
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            Genetic Interactions

            E2f2 role
            E2f2 genetic perturbation
            Interactor gene
            Interactor species
            Interactor role
            Interactor genetic perturbation
            Interaction type
            Phenotype or trait
            Source
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