Enables kinase regulator activity and ubiquitin-protein transferase activity. Involved in several processes, including protein K48-linked ubiquitination; regulation of Toll signaling pathway; and regulation of defense response. Located in cytoplasmic side of plasma membrane and cytosol. Is expressed in adult fat body and organism. Human ortholog(s) of this gene implicated in colorectal cancer. Orthologous to several human genes including PELI2 (pellino E3 ubiquitin protein ligase family member 2).
FB Description
Pellino (Pli) encodes a RING-domain-containing ubiquitin E3 ligase that coordinates with ubiquitin-activating (E1) and ubiquitin-conjugating (E2) enzymes to degrade target proteins. It functions as a negative regulator of the Toll-mediated innate immunity pathway.