Gene

Pli

Species
Drosophila melanogaster
Symbol
Pli
Name
Pellino
Synonyms
  • CG5212
  • PAP
Biotype
protein coding gene
Automated Description
Enables kinase regulator activity and ubiquitin-protein transferase activity. Involved in several processes, including protein K48-linked ubiquitination; regulation of Toll signaling pathway; and regulation of defense response. Located in cytoplasmic side of plasma membrane and cytosol. Is expressed in adult fat body and organism. Human ortholog(s) of this gene implicated in colorectal cancer. Orthologous to several human genes including PELI2 (pellino E3 ubiquitin protein ligase family member 2).
FB Description
Pellino (Pli) encodes a RING-domain-containing ubiquitin E3 ligase that coordinates with ubiquitin-activating (E1) and ubiquitin-conjugating (E2) enzymes to degrade target proteins. It functions as a negative regulator of the Toll-mediated innate immunity pathway.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR12098
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
R6
Viewer Help
23.865M23.870M23.875M23.880M23.885M23.890M

Sequence Details

Loading...

Expression

Primary Sources
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions