Gene

Eph

Species
Drosophila melanogaster
Symbol
Eph
Name
Eph receptor tyrosine kinase
Synonyms
  • CG1511
  • CT3831
Biotype
protein coding gene
Automated Description
Predicted to enable transmembrane-ephrin receptor activity. Involved in melanotic encapsulation of foreign target; mushroom body development; and peripheral nervous system development. Predicted to be located in membrane. Predicted to be part of receptor complex. Predicted to be active in plasma membrane. Is expressed in several structures, including adult head; eye disc posterior to the morphogenetic furrow; larval central nervous system; neuron projection bundle of larval ventral nerve cord; and synaptic neuropil domain. Human ortholog(s) of this gene implicated in several diseases, including autosomal dominant nonsyndromic deafness 88; cataract 6 multiple types; central conducting lymphatic anomaly; pancreatic cancer; and prostate cancer. Orthologous to several human genes including EPHA3 (EPH receptor A3); EPHA4 (EPH receptor A4); and EPHA5 (EPH receptor A5).
FB Description
Eph receptor tyrosine kinase (Eph) encodes an axon guidance molecule involved in the development of the nervous system. It also contributes to shaping the antero-posterior compartment boundary of the wing disc.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR24416
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
R6
Viewer Help
612k614k616k618k620k622k

Sequence Details

Loading...

Expression

Primary Sources
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions