Gene

Septin5

Species
Drosophila melanogaster
Symbol
Septin5
Name
Septin 5
Synonyms
  • CG2916
  • dSEPT5
Biotype
protein coding gene
Automated Description
Predicted to enable GTPase activity and molecular adaptor activity. Involved in imaginal disc-derived wing morphogenesis and regulation of cell cycle. Predicted to be part of septin complex. Predicted to be active in cell division site; microtubule cytoskeleton; and septin ring. Is expressed in several structures, including anterior endoderm; dorsal ectoderm anlage; endoderm anlage; foregut anlage; and foregut anlage in statu nascendi. Orthologous to human SEPTIN10 (septin 10).
FB Description
Septin 5 (Septin5) encodes a member of the septin family of GTP-binding proteins. Septins form hetero-oligomeric filaments and rings that have roles in cytokinesis, cell polarity and membrane rigidity. Septin5 is not essential for development, but mutants display a synthetic lethal pupal phenotype when combined with mutations in its paralog Septin2.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR18884
Stringency:
Additional filters to further constrain the results:
Species Gene symbol Count Best Best reverse
Method
Ensembl ComparaHGNCHieranoidInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidXenbaseZFIN
Homo sapiensSEPTIN108 of 9YesYes   
Mus musculusSeptin109 of 9YesYes   
Mus musculusSeptin68 of 9NoYes   
Rattus norvegicusSeptin108 of 9YesYes   
Xenopus tropicalisseptin107 of 9YesYes   
Xenopus tropicalisseptin86 of 9YesNo   
Danio rerioseptin108 of 10YesYes  
Caenorhabditis elegansunc-617 of 9YesNo   
Saccharomyces cerevisiaeCDC112 of 9YesYes   
Saccharomyces cerevisiaeSHS12 of 9YesYes   
Saccharomyces cerevisiaeCDC122 of 9YesYes   
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Gene symbolRank Alignment Length (aa) Similarity %Identity %Method Count
Method
Ensembl ComparaHGNCInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidSGD
Septin2140489757 of 8  
pnut244061393 of 8  
Septin1334962423 of 8  
Septin4438857382 of 8  

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
Phenotype Term
Annotation details
References
abnormal wound healing | embryonic stage
actomyosin | embryonic stage
fertile
viable
Showing 1 - 4 of 4 rows
per page

Disease Associations

Cases where the expected disease association was NOT found
Must provide at least one subject
Cell color indicative of annotation volume

Alleles and Variants

Genome location
Assembly version
R6
Viewer Help
7.9602M7.9604M7.9606M7.9608M7.9610M7.9612M7.9614M7.9616M7.9618M
Variant Types and ConsequencesOnly variants associated to alleles are shown in the graphics above. See all variants in JBrowse.
Allele/Variant Symbol
Allele Synonyms
Category
Variant
Variant type
Molecular consequence
Has Disease Annotations
Has Phenotype Annotations
Septin5G6155
  • Sep5[G6155]
  • Sep5G6155
allele with one associated variant
insertion
  • 5 prime UTR variant
Septin52
  • Sep5[2]
  • Sep52
allele with one associated variant
deletion
  • start lost
Yes
Septin5f04717
  • Sep5[f04717]
  • Sep5f04717
allele with one associated variant
insertion
  • 5 prime UTR variant
Septin51
  • Sep5[1]
  • Sep51
allele with one associated variant
deletion
  • stop lost
Yes
NT_033778.4:g.7960651G>Avariant
SNP
  • synonymous variant
NT_033778.4:g.7960975G>Cvariant
SNP
  • synonymous variant
NT_033778.4:g.7961172A>Cvariant
SNP
  • missense variant
NT_033778.4:g.7961837T>Avariant
SNP
  • splice region variant
NT_033778.4:g.7961676G>Avariant
SNP
  • 5 prime UTR variant
NT_033778.4:g.7961884G>Tvariant
SNP
  • 5 prime UTR variant
Showing 1 - 10 of 31 rows
per page

Transgenic Alleles

Species
(carrying the transgene)
Allele symbol
Transgenic construct
Expressed components
Knock-down targets
Regulatory regions
Has Disease Annotations
Has Phenotype Annotations
Drosophila melanogasterSeptin5GD16661
  • UASt
Drosophila melanogasterSeptin5GD9852
  • UASt
Drosophila melanogasterSeptin5JF01771
  • UAS
Drosophila melanogasterSeptin5KK109733
  • UASt
Drosophila melanogasterSeptin5NIG.2916R
  • UASt
Drosophila melanogasterSeptin5U6.NIG.sgRNA
Drosophila melanogasterSeptin5UASp.GFP
  • UASp
Drosophila melanogasterSeptin5UASp.cOa
  • UASp
Drosophila melanogasterSeptin5UASp.cSa.EGFP
  • UASp
Drosophila melanogasterSeptin5UASp.mRFP(Unk)
  • UASp
Showing 1 - 10 of 10 rows
per page

Models

No data available

Sequence Feature Viewer

Genome location
Assembly version
R6
Viewer Help
7.9602M7.9604M7.9606M7.9608M7.9610M7.9612M7.9614M7.9616M7.9618M

Sequence Details

Loading...

Expression

Primary Sources
Other Sources
Must provide at least one subject
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

5 interactor genes based on 6 annotations
Septin5 molecule type
Interactor gene
Interactor species
Interactor molecule type
Detection methods
Source
Reference
protein
pnutDrosophila melanogaster
protein
  • experimental knowledge based
PMID:22036573
protein
pnutDrosophila melanogaster
protein
  • anti bait coimmunoprecipitation
PMID:23447705
protein
scraDrosophila melanogaster
protein
  • anti tag coimmunoprecipitation
PMID:18349071
protein
Septin1Drosophila melanogaster
protein
  • experimental knowledge based
PMID:22036573
protein
Septin2Drosophila melanogaster
protein
  • experimental knowledge based
PMID:22036573
Showing 1 - 5 of 5 rows
per page

Genetic Interactions

Septin5 role
Septin5 genetic perturbation
Interactor gene
Interactor species
Interactor role
Interactor genetic perturbation
Interaction type
Phenotype or trait
Source
Reference
enhancer gene
bazDrosophila melanogaster
enhanced gene
genetic enhancement
    PMID:20368978
    Showing 1 - 1 of 1 rows
    per page