Gene

ear

Species
Drosophila melanogaster
Symbol
ear
Name
ENL/AF9-related
Synonyms
  • CG4913
  • dENL/AF9
Biotype
protein coding gene
Automated Description
Predicted to enable histone binding activity. Predicted to be involved in chromatin remodeling; regulation of transcription by RNA polymerase II; and transcription initiation at RNA polymerase II promoter. Part of super elongation complex. Is expressed in organism. Orthologous to human MLLT1 (MLLT1 super elongation complex subunit) and MLLT3 (MLLT3 super elongation complex subunit).
FB Description
ENL/AF9-related (ear) encodes a transcription factor that is a component of the super elongation complex (SEC), which regulates transcription by RNA Polymerase II. It also interacts with the histone methyltransferase encoded by gpp in the Dot1 complex (DotCom), which modifies chromatin structure by methylating histone H3 on lysine 79.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR23195
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
R6
Viewer Help
15.3210M15.3215M15.3220M15.3225M15.3230M15.3235M15.3240M15.3245M15.3250M

Sequence Details

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Expression

Primary Sources
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions