Version: 8.0.0
Date: Tue Jan 28 2025
cindr
Drosophila melanogasterFB:FBgn0027598
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

cindr

Species
Drosophila melanogaster
Symbol
cindr
Name
CIN85 and CD2AP related
Synonyms
  • BcDNA:GH03163
  • CD2AP
Biotype
protein coding gene
Automated Description
Enables GTPase activating protein binding activity; SH3 domain binding activity; and cell adhesion molecule binding activity. Involved in several processes, including adherens junction assembly; border follicle cell migration; and positive regulation of receptor-mediated endocytosis. Located in several cellular components, including cleavage furrow; fusome; and midbody. Is active in apical cortex; neuromuscular junction; and presynapse. Is expressed in several structures, including adult head; adult head sensillum; germline cell; imaginal disc; and pigment cell. Used to study nephrotic syndrome and tauopathy. Human ortholog(s) of this gene implicated in focal segmental glomerulosclerosis; focal segmental glomerulosclerosis 3; and immunodeficiency 61. Orthologous to human CD2AP (CD2 associated protein) and SH3KBP1 (SH3 domain containing kinase binding protein 1).
FB Description
CIN85 and CD2AP related (cindr) encodes an adaptor protein that links cell surface junctions and adhesion proteins with multiple components of the actin cytoskeleton. It regulates cytoskeletal dynamics, eye patterning and endocytosis. It also cooperates with the product of scra to promote intercellular bridge stability during cytokinesis.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR14167
No data available
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
Phenotype Term
Annotation details
References
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume
    Gene
    Association
    Disease Qualifier
    Disease
    Evidence
    Source
    Based On
    References
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      Alleles and Variants

      Allele/Variant Symbol
      Allele Synonyms
      Category
      Variant
      Variant type
      Molecular consequence
      Has Disease Annotations
      Has Phenotype Annotations
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        Transgenic Alleles

        Species
        (carrying the transgene)
        Allele symbol
        Transgenic construct
        Expressed components
        Knock-down targets
        Regulatory regions
        Has Disease Annotations
        Has Phenotype Annotations
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          Models

          Model name
          Experimental condition
          Associated Human Diseases
          Associated Phenotypes
          Modifier
          Source
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            Sequence Feature Viewer

            Genome location
            Assembly version
            R6
            Viewer Help
            30.810M30.812M30.814M30.816M30.818M30.820M30.822M30.824M30.826M

            Sequence Details

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            Expression

            Primary Sources
            Other Sources
            Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

            Molecular Interactions

            cindr molecule type
            Interactor gene
            Interactor species
            Interactor molecule type
            Detection methods
            Source
            Reference
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              Genetic Interactions

              cindr role
              cindr genetic perturbation
              Interactor gene
              Interactor species
              Interactor role
              Interactor genetic perturbation
              Interaction type
              Phenotype or trait
              Source
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