Gene

Ulp1

Species
Drosophila melanogaster
Symbol
Ulp1
Name
Ulp1
Synonyms
  • BcDNA:GH02751
  • CG12359
Biotype
protein coding gene
Automated Description
Enables deSUMOylase activity. Involved in several processes, including negative regulation of signal transduction; neuron projection morphogenesis; and protein destabilization. Located in cytoplasm and nuclear inner membrane. Part of nuclear pore. Is expressed in several structures, including germarium; germline cell; gonad; and larval central nervous system. Orthologous to human SENP2 (SUMO specific peptidase 2).
FB Description
Ulp1 (Ulp1) encodes a cysteine protease that catalyzes both SUMO maturation and SUMO deconjugation. It localizes to the nucleoplasmic face of the nuclear pore complex. Ulp1 knockdown in S2 cells results in relocalization of SUMO from the nucleus to the cytoplasm.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR12606
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Gene symbolRank Alignment Length (aa) Similarity %Identity %Method Count
Method
Ensembl ComparaHGNCInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidSGD
CG32110141156415 of 8  
Den1217137252 of 8  

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
Phenotype Term
Annotation details
References
fertile
lethal | recessive
male sterile
viable
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Disease Associations

Cases where the expected disease association was NOT found
Must provide at least one subject
Cell color indicative of annotation volume

Transgenic Alleles

Models

No data available

Sequence Feature Viewer

Genome location
Assembly version
R6
Viewer Help
19.203M19.204M19.205M19.206M19.207M19.208M

Sequence Details

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Expression

Primary Sources
Other Sources
Must provide at least one subject
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions

Ulp1 role
Ulp1 genetic perturbation
Interactor gene
Interactor species
Interactor role
Interactor genetic perturbation
Interaction type
Phenotype or trait
Source
Reference
suppressor gene
smoDrosophila melanogaster
suppressed gene
genetic suppression
    PMID:28195188
    suppressor gene
    veloDrosophila melanogaster
    suppressed gene
    genetic suppression
      PMID:22699913
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