Gene

ric8a

Species
Drosophila melanogaster
Symbol
ric8a
Name
ric8a
Synonyms
  • CG15797
  • DmRic8
Biotype
protein coding gene
Automated Description
Enables G-protein alpha-subunit binding activity. Involved in several processes, including establishment of mitotic spindle localization; gastrulation involving germ band extension; and protein stabilization. Located in cytosol; type Ib terminal bouton; and type Is terminal bouton. Is expressed in organism. Orthologous to several human genes including RIC8A (RIC8 guanine nucleotide exchange factor A).
FB Description
ric8a (ric8a) encodes a guanine nucleotide-exchange factor for the product of Galphai. Its function is necessary to ensure cortical localization of the heterotrimeric subunits encoded by Galphai and Gbeta13F, thereby regulating spindle orientation during asymmetric cell division in the sensory lineage.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR12425
No data available
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Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

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    Disease Associations

    Cases where the expected disease association was NOT found
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      Alleles and Variants

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        Transgenic Alleles

        Species
        (carrying the transgene)
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          Models

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            Sequence Feature Viewer

            Genome location
            Assembly version
            R6
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            9.2565M9.2570M9.2575M9.2580M9.2585M9.2590M

            Sequence Details

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            Expression

            Primary Sources
            Other Sources
            Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

            Molecular Interactions

            ric8a molecule type
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              Genetic Interactions

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              ric8a genetic perturbation
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