Predicted to enable protein phosphatase 2A binding activity. Predicted to be involved in mitotic nuclear membrane reassembly. Located in endoplasmic reticulum and nuclear envelope. Is expressed in adult brain cell body rind; central brain primordium; embryonic brain; and organism. Used to study microcephaly and primary autosomal recessive microcephaly 16. Human ortholog(s) of this gene implicated in primary autosomal recessive microcephaly 16. Orthologous to human ANKLE2 (ankyrin repeat and LEM domain containing 2).
FB Description
Ankle2 (Ankle2) encodes an important protein for proper development of the third instar larval CNS. Ankle2 loss causes a small brain phenotype, defects in proliferation and excessive apoptosis.