Gene

Ankle2

Species
Drosophila melanogaster
Symbol
Ankle2
Name
Ankle2
Synonyms
  • Ankle-2
  • ANKLE2 ortholog
Biotype
protein coding gene
Automated Description
Predicted to enable protein phosphatase 2A binding activity. Predicted to be involved in mitotic nuclear membrane reassembly. Located in endoplasmic reticulum and nuclear envelope. Is expressed in adult brain cell body rind; central brain primordium; embryonic brain; and organism. Used to study microcephaly and primary autosomal recessive microcephaly 16. Human ortholog(s) of this gene implicated in primary autosomal recessive microcephaly 16. Orthologous to human ANKLE2 (ankyrin repeat and LEM domain containing 2).
FB Description
Ankle2 (Ankle2) encodes an important protein for proper development of the third instar larval CNS. Ankle2 loss causes a small brain phenotype, defects in proliferation and excessive apoptosis.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR12349
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
R6
Viewer Help
17.572M17.573M17.574M17.575M17.576M17.577M17.578M17.579M

Sequence Details

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Expression

Primary Sources
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions