Version: 8.0.0
Date: Tue Jan 28 2025
Vha16-2
Drosophila melanogasterFB:FBgn0028668
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

Vha16-2

Species
Drosophila melanogaster
Symbol
Vha16-2
Name
Vacuolar H[+] ATPase 16kD subunit 2
Synonyms
  • CG32089
  • CG7547
Biotype
protein coding gene
Automated Description
Predicted to contribute to proton-transporting ATPase activity, rotational mechanism. Predicted to be involved in proton transmembrane transport. Predicted to be part of vacuolar proton-transporting V-type ATPase, V0 domain. Predicted to be active in membrane. Human ortholog(s) of this gene implicated in early-onset epilepsy 3 and thyroid gland carcinoma. Orthologous to human ATP6V0C (ATPase H+ transporting V0 subunit c).
FB Description
Vacuolar H[+] ATPase 16kD subunit 2 (Vha16-2) encodes the main subunit of the membrane-embedded V0 sector of the vacuolar-ATPase, which is responsible for acidification of the endo-lysosomal lumen and other cellular compartment. As part of the V-ATPase, the product of Vha16-2 supports membrane trafficking, protein degradation and multiple associated signaling pathways, such as mTor, Wnt and Notch.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR10263
No data available
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
Phenotype Term
Annotation details
References
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume
    Gene
    Association
    Disease Qualifier
    Disease
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      Alleles and Variants

      Allele/Variant Symbol
      Allele Synonyms
      Category
      Variant
      Variant type
      Molecular consequence
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        Transgenic Alleles

        Species
        (carrying the transgene)
        Allele symbol
        Transgenic construct
        Expressed components
        Knock-down targets
        Regulatory regions
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          Models

          Model name
          Experimental condition
          Associated Human Diseases
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            Sequence Feature Viewer

            Genome location
            Assembly version
            R6
            Viewer Help
            11.4750M11.4751M11.4752M11.4753M11.4754M11.4755M

            Sequence Details

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            Expression

            Primary Sources
            Other Sources
            Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

            Molecular Interactions

            Vha16-2 molecule type
            Interactor gene
            Interactor species
            Interactor molecule type
            Detection methods
            Source
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              Genetic Interactions

              Vha16-2 role
              Vha16-2 genetic perturbation
              Interactor gene
              Interactor species
              Interactor role
              Interactor genetic perturbation
              Interaction type
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