Enables zinc ion binding activity. Involved in proteasome-mediated ubiquitin-dependent protein catabolic process. Acts upstream of with a positive effect on determination of adult lifespan. Part of proteasome regulatory particle. Is expressed in adult head; adult heart; and spermatozoon. Used to study neurodegenerative disease. Orthologous to human PSMD2 (proteasome 26S subunit ubiquitin receptor, non-ATPase 2).
FB Description
Regulatory particle non-ATPase 1 (Rpn1) encodes a component of the 26S proteasome, which degrades polyubiquitinated proteins in the cytoplasm and nucleus.