Gene

Rpn1

Species
Drosophila melanogaster
Symbol
Rpn1
Name
Regulatory particle non-ATPase 1
Synonyms
  • BcDNA:LD21723
  • CG7762
Biotype
protein coding gene
Automated Description
Enables zinc ion binding activity. Involved in proteasome-mediated ubiquitin-dependent protein catabolic process. Acts upstream of with a positive effect on determination of adult lifespan. Part of proteasome regulatory particle. Is expressed in adult head; adult heart; and spermatozoon. Used to study neurodegenerative disease. Orthologous to human PSMD2 (proteasome 26S subunit ubiquitin receptor, non-ATPase 2).
FB Description
Regulatory particle non-ATPase 1 (Rpn1) encodes a component of the 26S proteasome, which degrades polyubiquitinated proteins in the cytoplasm and nucleus.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR10943
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
R6
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19.9155M19.9160M19.9165M19.9170M19.9175M19.9180M

Sequence Details

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Expression

Primary Sources
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions