Gene

GMF

Species
Drosophila melanogaster
Symbol
GMF
Name
Glia maturation factor
Synonyms
  • BcDNA:SD03793
  • BG:DS02740.9
Biotype
protein coding gene
Automated Description
Predicted to enable Arp2/3 complex binding activity. Involved in several processes, including actin filament debranching; border follicle cell migration; and regulation of actin filament organization. Located in several cellular components, including lamellipodium; nucleus; and perinuclear region of cytoplasm. Is expressed in border follicle cell; centripetal follicle cell; and polar follicle cell. Orthologous to human GMFB (glia maturation factor beta) and GMFG (glia maturation factor gamma).
FB Description
Glia maturation factor (GMF) encodes a protein belonging to the ADF-H domain family of proteins, which promote dissambly of actin networks. It specifically binds to and promotes disassembly of Arp2/3-nucleated lamellipodial actin networks. It plays a role in promoting protrusion dynamics during cell migration.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR11249
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
R6
Viewer Help
16.3018M16.3020M16.3022M16.3024M16.3026M16.3028M

Sequence Details

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Expression

Primary Sources
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions