Predicted to enable Arp2/3 complex binding activity. Involved in several processes, including actin filament debranching; border follicle cell migration; and regulation of actin filament organization. Located in several cellular components, including lamellipodium; nucleus; and perinuclear region of cytoplasm. Is expressed in border follicle cell; centripetal follicle cell; and polar follicle cell. Orthologous to human GMFB (glia maturation factor beta) and GMFG (glia maturation factor gamma).
FB Description
Glia maturation factor (GMF) encodes a protein belonging to the ADF-H domain family of proteins, which promote dissambly of actin networks. It specifically binds to and promotes disassembly of Arp2/3-nucleated lamellipodial actin networks. It plays a role in promoting protrusion dynamics during cell migration.