Enables endopeptidase activity. Involved in cell migration and protein processing. Located in extracellular space. Is expressed in egg; female reproductive system; oviduct; and uterus. Used to study prostate cancer. Orthologous to human MEP1A (meprin A subunit alpha) and MEP1B (meprin A subunit beta).
FB Description
Seminal metalloprotease-1 (Semp1) encodes a metalloprotease that is produced by male accessory glands and transferred to females during mating. It is cleavage activated during mating, first by the product of Sems and then by auto-catalysis. The product of also cleaves at least two other seminal proteins, encoded by Acp26Aa and Acp36DE, in the mated female.