Gene

Semp1

Species
Drosophila melanogaster
Symbol
Semp1
Name
Seminal metalloprotease-1
Synonyms
  • AST
  • BACR44L22.8
Biotype
protein coding gene
Automated Description
Enables endopeptidase activity. Involved in cell migration and protein processing. Located in extracellular space. Is expressed in egg; female reproductive system; oviduct; and uterus. Used to study prostate cancer. Orthologous to human MEP1A (meprin A subunit alpha) and MEP1B (meprin A subunit beta).
FB Description
Seminal metalloprotease-1 (Semp1) encodes a metalloprotease that is produced by male accessory glands and transferred to females during mating. It is cleavage activated during mating, first by the product of Sems and then by auto-catalysis. The product of also cleaves at least two other seminal proteins, encoded by Acp26Aa and Acp36DE, in the mated female.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR10127
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
R6
Viewer Help
15.6125M15.6126M15.6127M15.6128M15.6129M15.6130M15.6131M15.6132M15.6133M

Sequence Details

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Expression

Primary Sources
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions