Gene

Surf1

Species
Drosophila melanogaster
Symbol
Surf1
Name
Surfeit 1
Synonyms
  • BcDNA:GH23574
  • CG9943
Biotype
protein coding gene
Automated Description
Involved in several processes, including mitochondrial respirasome assembly; phototaxis; and visual behavior. Predicted to be located in mitochondrial inner membrane. Predicted to be active in mitochondrion. Is expressed in adult head. Used to study Leigh disease and mitochondrial complex IV deficiency nuclear type 1. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease type 4K; Leigh disease; and mitochondrial complex IV deficiency nuclear type 1. Orthologous to human SURF1 (SURF1 cytochrome c oxidase assembly factor).
FB Description
Surfeit 1 (Surf1) encodes a nuclear gene encoding a protein that might be involved in the assembly of the mitochondrial respiratory chain Cytochrome Oxidase (COX or Complex IV). Mutations in its human ortholog Surf1 are related to Leigh Syndrome with COX deficiency (LScox). Surf1 RNAi knockdown produces many of the hallmark signs of LScox, albeit with a more complex biochemical profile.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR23427
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
R6
Viewer Help
6.9584M6.9586M6.9588M6.9590M6.9592M6.9594M

Sequence Details

Loading...

Expression

Primary Sources
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions