Version: 8.0.0
Date: Tue Jan 28 2025
Aos1
Drosophila melanogasterFB:FBgn0029512
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

Aos1

Species
Drosophila melanogaster
Symbol
Aos1
Name
Activator of SUMO 1
Synonyms
  • Aos
  • AOS1
Biotype
protein coding gene
Automated Description
Enables ubiquitin activating enzyme binding activity and ubiquitin conjugating enzyme binding activity. Contributes to SUMO activating enzyme activity. Involved in several processes, including positive regulation of Toll signaling pathway; positive regulation of antimicrobial peptide production; and protein sumoylation. Located in nucleus. Is expressed in several structures, including Malpighian tubule primordium; antennal anlage; ganglia; germline cell; and head epidermis primordium. Used to study hematologic cancer. Orthologous to human SAE1 (SUMO1 activating enzyme subunit 1).
FB Description
Activator of SUMO 1 (Aos1) encodes one of two subunits (along with the product of Uba2) of the heterodimeric SUMO activating enzyme.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR10953
No data available
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Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
Phenotype Term
Annotation details
References
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume
    Gene
    Association
    Disease Qualifier
    Disease
    Evidence
    Source
    Based On
    References
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      Alleles and Variants

      Allele/Variant Symbol
      Allele Synonyms
      Category
      Variant
      Variant type
      Molecular consequence
      Has Disease Annotations
      Has Phenotype Annotations
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        Transgenic Alleles

        Species
        (carrying the transgene)
        Allele symbol
        Transgenic construct
        Expressed components
        Knock-down targets
        Regulatory regions
        Has Disease Annotations
        Has Phenotype Annotations
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          Models

          Model name
          Experimental condition
          Associated Human Diseases
          Associated Phenotypes
          Modifier
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            Sequence Feature Viewer

            Genome location
            Assembly version
            R6
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            12.4326M12.4328M12.4330M12.4332M12.4334M12.4336M12.4338M

            Sequence Details

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            Expression

            Primary Sources
            Other Sources
            Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

            Molecular Interactions

            Aos1 molecule type
            Interactor gene
            Interactor species
            Interactor molecule type
            Detection methods
            Source
            Reference
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              Genetic Interactions

              Aos1 role
              Aos1 genetic perturbation
              Interactor gene
              Interactor species
              Interactor role
              Interactor genetic perturbation
              Interaction type
              Phenotype or trait
              Source
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