ADAM metallopeptidase with thrombospondin type 1 motif B
Synonyms
AdamTS-B
CG4096
Biotype
protein coding gene
Automated Description
Predicted to enable metalloendopeptidase activity. Involved in negative regulation of epidermal growth factor receptor signaling pathway and negative regulation of imaginal disc-derived wing vein specification. Predicted to be active in extracellular matrix. Is expressed in several structures, including clypeo-labral primordium; dorsal epidermis primordium; embryonic epipharynx; embryonic hypopharynx; and presumptive wing vein. Human ortholog(s) of this gene implicated in Weill-Marchesani syndrome and congenital heart disease. Orthologous to several human genes including ADAMTS12 (ADAM metallopeptidase with thrombospondin type 1 motif 12) and ADAMTS7 (ADAM metallopeptidase with thrombospondin type 1 motif 7).