Gene

Sk1

Species
Drosophila melanogaster
Symbol
Sk1
Name
Sphingosine kinase 1
Synonyms
  • CG1747
  • sk1
Biotype
protein coding gene
Automated Description
Enables D-erythro-sphingosine kinase activity. Involved in sphingolipid metabolic process. Located in cytosol and plasma membrane. Is expressed in adult head; embryonic/larval midgut primordium; gut section; and mesoderm. Used to study cardiomyopathy. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Orthologous to several human genes including SPHK2 (sphingosine kinase 2).
FB Description
Sphingosine kinase 1 (Sk1) encodes an enzyme that catalyzes the phosphorylation of sphingosine to sphingosine 1-phosphate, a bioactive lipid mediator. It regulates cell proliferation, differentiation, endolysosomal trafficking and muscle cell repair.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR12358
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
R6
Viewer Help
11.4430M11.4435M11.4440M11.4445M11.4450M11.4455M11.4460M

Sequence Details

Loading...

Expression

Primary Sources
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions