Enables D-erythro-sphingosine kinase activity. Involved in sphingolipid metabolic process. Located in cytosol and plasma membrane. Is expressed in adult head; embryonic/larval midgut primordium; gut section; and mesoderm. Used to study cardiomyopathy. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Orthologous to several human genes including SPHK2 (sphingosine kinase 2).
FB Description
Sphingosine kinase 1 (Sk1) encodes an enzyme that catalyzes the phosphorylation of sphingosine to sphingosine 1-phosphate, a bioactive lipid mediator. It regulates cell proliferation, differentiation, endolysosomal trafficking and muscle cell repair.