Enables [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity. Involved in heparan sulfate proteoglycan biosynthetic process, enzymatic modification. Human ortholog(s) of this gene implicated in colon cancer; hereditary angioedema; lung cancer; lung non-small cell carcinoma; and pancreatic cancer. Orthologous to several human genes including HS3ST2 (heparan sulfate-glucosamine 3-sulfotransferase 2).
FB Description
Heparan sulfate 3-O sulfotransferase-B (Hs3st-B) encodes a heparan sulfate modifying enzyme that transfers a sulfate group to the 3-O position of glucosamine residues of heparan sulfate. It regulates adult midgut homeostasis.