Version: 8.0.0
Date: Tue Jan 28 2025
Hs3st-B
Drosophila melanogasterFB:FBgn0031005
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

Hs3st-B

Species
Drosophila melanogaster
Symbol
Hs3st-B
Name
Heparan sulfate 3-O sulfotransferase-B
Synonyms
  • 3-O-sulfotransferase
  • CG7890
Biotype
protein coding gene
Automated Description
Enables [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity. Involved in heparan sulfate proteoglycan biosynthetic process, enzymatic modification. Human ortholog(s) of this gene implicated in colon cancer; hereditary angioedema; lung cancer; lung non-small cell carcinoma; and pancreatic cancer. Orthologous to several human genes including HS3ST2 (heparan sulfate-glucosamine 3-sulfotransferase 2).
FB Description
Heparan sulfate 3-O sulfotransferase-B (Hs3st-B) encodes a heparan sulfate modifying enzyme that transfers a sulfate group to the 3-O position of glucosamine residues of heparan sulfate. It regulates adult midgut homeostasis.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR10605
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
Phenotype Term
Annotation details
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume
    No data available

    Alleles and Variants

    Allele/Variant Symbol
    Allele Synonyms
    Category
    Variant
    Variant type
    Molecular consequence
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      Transgenic Alleles

      Species
      (carrying the transgene)
      Allele symbol
      Transgenic construct
      Expressed components
      Knock-down targets
      Regulatory regions
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      Has Phenotype Annotations
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        Models

        Model name
        Experimental condition
        Associated Human Diseases
        Associated Phenotypes
        Modifier
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          Sequence Feature Viewer

          Genome location
          Assembly version
          R6
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          Data currently unavailable; sequence viewer under construction

          Sequence Details

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          Expression

          Primary Sources
          Other Sources
          Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

          Molecular Interactions

          Hs3st-B molecule type
          Interactor gene
          Interactor species
          Interactor molecule type
          Detection methods
          Source
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            Genetic Interactions

            Hs3st-B role
            Hs3st-B genetic perturbation
            Interactor gene
            Interactor species
            Interactor role
            Interactor genetic perturbation
            Interaction type
            Phenotype or trait
            Source
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