Gene

ND-18

Species
Drosophila melanogaster
Symbol
ND-18
Name
NADH dehydrogenase (ubiquinone) 18 kDa subunit
Synonyms
  • CG12203
  • dNDUFS4
Biotype
protein coding gene
Automated Description
Predicted to be involved in mitochondrial respiratory chain complex I assembly. Part of respiratory chain complex I. Is expressed in several structures, including Malpighian tubule primordium; adult head; adult heart; embryonic/larval midgut primordium; and gut section. Used to study mitochondrial complex I deficiency. Human ortholog(s) of this gene implicated in Leigh disease and nuclear type mitochondrial complex I deficiency 1. Orthologous to human NDUFS4 (NADH:ubiquinone oxidoreductase subunit S4).
FB Description
Not Available
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR12219
Stringency:
Additional filters to further constrain the results:
Species Gene symbol Count Best Best reverse
Method
Ensembl ComparaHGNCHieranoidInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidXenbaseZFIN
Homo sapiensNDUFS49 of 9YesYes   
Mus musculusNdufs49 of 9YesYes   
Rattus norvegicusNdufs49 of 9YesYes   
Xenopus tropicalisndufs49 of 9YesYes   
Danio reriondufs49 of 10YesYes  
Caenorhabditis eleganslpd-59 of 9YesYes   
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

No paralogs for the gene.

Function - GO Annotations

No function available for that gene

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
No data available

Disease Associations

Cases where the expected disease association was NOT found
Must provide at least one subject
Cell color indicative of annotation volume

Alleles and Variants

Genome location
Assembly version
R6
Viewer Help
19.4925M19.4926M19.4927M19.4928M19.4929M19.4930M19.4931M19.4932M19.4933M
Variant Types and ConsequencesOnly variants associated to alleles are shown in the graphics above. See all variants in JBrowse.
Allele/Variant Symbol
Allele Synonyms
Category
Variant
Variant type
Molecular consequence
Has Disease Annotations
Has Phenotype Annotations
NC_004354.4:g.19492572C>Tvariant
SNP
  • synonymous variant
NC_004354.4:g.19492818T>Gvariant
SNP
  • synonymous variant
NC_004354.4:g.19492977G>Cvariant
SNP
  • synonymous variant
NC_004354.4:g.19493013G>Avariant
SNP
  • intron variant
NC_004354.4:g.19492627G>Avariant
SNP
  • intron variant
NC_004354.4:g.19492548C>Tvariant
SNP
  • synonymous variant
NC_004354.4:g.19492512C>Tvariant
SNP
  • 5 prime UTR variant
NC_004354.4:g.19492590G>Cvariant
SNP
  • splice region variant
NC_004354.4:g.19492728C>Tvariant
SNP
  • synonymous variant
NC_004354.4:g.19492810G>Avariant
SNP
  • missense variant
Showing 1 - 10 of 17 rows
per page

Transgenic Alleles

Species
(carrying the transgene)
Allele symbol
Transgenic construct
Expressed components
Knock-down targets
Regulatory regions
Has Disease Annotations
Has Phenotype Annotations
Drosophila melanogasterND-18GD7526
  • UASt
Drosophila melanogasterND-18HMC03554
  • UAS
Drosophila melanogasterND-18KK108847
  • UASt
Yes
Drosophila melanogasterND-18NIG.12203R
  • UASt
Drosophila melanogasterND-18TKO.GS03496
Drosophila melanogasterND-18TOE.GS01554
Drosophila melanogasterND-18UAS.ORF.GW.Tag:HA
  • UASt
Showing 1 - 7 of 7 rows
per page

Models

No data available

Sequence Feature Viewer

Genome location
Assembly version
R6
Viewer Help
19.4925M19.4926M19.4927M19.4928M19.4929M19.4930M19.4931M19.4932M19.4933MND-18-RA (ND-18)CG12204-RA (CG12204)

Sequence Details

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Expression

Primary Sources
Other Sources
Must provide at least one subject
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

17 interactor genes based on 17 annotations
ND-18 molecule type
Interactor gene
Interactor species
Interactor molecule type
Detection methods
Source
Reference
protein
Act88FDrosophila melanogaster
protein
  • experimental knowledge based
PMID:22036573
protein
AdhDrosophila melanogaster
protein
  • experimental knowledge based
PMID:22036573
protein
bowlDrosophila melanogaster
protein
  • two hybrid
PMID:14605208
protein
CaperDrosophila melanogaster
protein
  • two hybrid
PMID:14605208
protein
COX7AL2Drosophila melanogaster
protein
  • experimental knowledge based
PMID:22036573
protein
Cs1Drosophila melanogaster
protein
  • experimental knowledge based
PMID:22036573
protein
flnDrosophila melanogaster
protein
  • experimental knowledge based
PMID:22036573
protein
Gpdh1Drosophila melanogaster
protein
  • experimental knowledge based
PMID:22036573
protein
Gpo1Drosophila melanogaster
protein
  • experimental knowledge based
PMID:22036573
protein
GstS1Drosophila melanogaster
protein
  • experimental knowledge based
PMID:22036573
Showing 1 - 10 of 17 rows
per page

Genetic Interactions

No data available