Gene

shv

Species
Drosophila melanogaster
Symbol
shv
Name
shriveled
Synonyms
  • CG4164
  • shriveled
Biotype
protein coding gene
Automated Description
Enables integrin binding activity. Involved in several processes, including germ-line stem-cell niche homeostasis; male germ-line stem cell population maintenance; and positive regulation of integrin-mediated signaling pathway. Located in extracellular space and neuromuscular junction. Is expressed in several structures, including adult head; circulatory system primordium; ganglia; male germline cell; and somatic cell of testis. Human ortholog(s) of this gene implicated in polycystic kidney disease 6. Orthologous to human DNAJB11 (DnaJ heat shock protein family (Hsp40) member B11).
FB Description
shriveled (shv) encodes a secreted protein that activates integrin signaling. It is involved in synapse maturation regulation and stem cell maintenance.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR44298
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
R6
Viewer Help
453.2k453.4k453.6k453.8k454.0k454.2k454.4k454.6k

Sequence Details

Loading...

Expression

Primary Sources
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions