Enables integrin binding activity. Involved in several processes, including germ-line stem-cell niche homeostasis; male germ-line stem cell population maintenance; and positive regulation of integrin-mediated signaling pathway. Located in extracellular space and neuromuscular junction. Is expressed in several structures, including adult head; circulatory system primordium; ganglia; male germline cell; and somatic cell of testis. Human ortholog(s) of this gene implicated in polycystic kidney disease 6. Orthologous to human DNAJB11 (DnaJ heat shock protein family (Hsp40) member B11).
FB Description
shriveled (shv) encodes a secreted protein that activates integrin signaling. It is involved in synapse maturation regulation and stem cell maintenance.