Version: 8.0.0
Date: Tue Jan 28 2025
VGlut1
Drosophila melanogasterFB:FBgn0031424
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

VGlut1

Species
Drosophila melanogaster
Symbol
VGlut1
Name
Vesicular glutamate transporter 1
Synonyms
  • CG9887
  • Drosophila Vesicular Glutamate Transporter
Biotype
protein coding gene
Automated Description
Enables neurotransmitter transmembrane transporter activity. Involved in several processes, including glutamatergic synaptic transmission; positive regulation of neuromuscular synaptic transmission; and regulation of membrane potential in photoreceptor cell. Located in synaptic vesicle. Is expressed in several structures, including ganglia; neurons; organism subdivision; synaptic neuropil domain; and synaptic neuropil subdomain. Used to study Parkinson's disease and neurodegenerative disease. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 25. Orthologous to several human genes including SLC17A7 (solute carrier family 17 member 7) and SLC17A8 (solute carrier family 17 member 8).
FB Description
Vesicular glutamate transporter 1 (VGlut1) encodes a glutamate transporter belonging to SLC family of transporters. It localizes to synaptic vesicles in either glutamatergic or dopaminergic nerve terminals. It has been associated with neurodegenerative processes, regulation of basal and stimulant-induced locomotion, as well as the loading of glutamate and dopamine neurotransmitters into synaptic vesicles and vesicle co-transmission.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR11662
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

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    Disease Associations

    Cases where the expected disease association was NOT found
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    Alleles and Variants

    Allele/Variant Symbol
    Allele Synonyms
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      Transgenic Alleles

      Species
      (carrying the transgene)
      Allele symbol
      Transgenic construct
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      Knock-down targets
      Regulatory regions
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        Models

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          Sequence Feature Viewer

          Genome location
          Assembly version
          R6
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          Data currently unavailable; sequence viewer under construction

          Sequence Details

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          Expression

          Primary Sources
          Other Sources
          Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

          Molecular Interactions

          VGlut1 molecule type
          Interactor gene
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            Genetic Interactions

            VGlut1 role
            VGlut1 genetic perturbation
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