Predicted to enable ubiquitin protein ligase activity and zinc ion binding activity. Predicted to be involved in double-strand break repair via homologous recombination and protein ubiquitination. Predicted to be part of Smc5-Smc6 complex. Predicted to be active in nucleus. Is expressed in organism. Orthologous to human NSMCE1 (NSE1 homolog, SMC5-SMC6 complex component).
FB Description
Non-SMC element 1 (Nse1) encodes a RING finger protein with E3 ubiquitin ligase activity that is part of the SMC5/6 protein complex. This complex is critical to genome stability, and is required for homologous DNA recombination-based processes.