Involved in negative regulation of programmed cell death and oogenesis. Located in nucleolus. Is expressed in several structures, including adult head; anterior endoderm; anterior endoderm anlage; embryonic/larval midgut primordium; and larval muscle cell. Used to study chromosome 17q12 deletion syndrome. Orthologous to human AATF (apoptosis antagonizing transcription factor).
FB Description
Apoptosis antagonizing transcription factor (Aatf) encodes a transcription factor that is a target of the kinases encoded by tefu and lok. It is involved in the control of the cell cycle, DNA damage response, and regulation of apoptosis.