Gene

Kdm4A

Species
Drosophila melanogaster
Symbol
Kdm4A
Name
Lysine demethylase 4A
Synonyms
  • CG15835
  • dJMJD2(1)
Biotype
protein coding gene
Automated Description
Enables histone H3K36me2/H3K36me3 demethylase activity; histone H3K56me2/H3K56me3 demethylase activity; and histone H3K9me2/H3K9me3 demethylase activity. Involved in positive regulation of gene expression. Located in heterochromatin and nucleus. Is expressed in anterior endoderm anlage; head mesoderm; organism; posterior endoderm; and trunk mesoderm. Human ortholog(s) of this gene implicated in several diseases, including autistic disorder; gastrointestinal system cancer (multiple); head and neck cancer; malignant peripheral nerve sheath tumor; and withdrawal disorder. Orthologous to several human genes including KDM4A (lysine demethylase 4A) and KDM4C (lysine demethylase 4C).
FB Description
Lysine (K)-specific demethylase 4A (Kdm4A) encodes a histone lysine demethylase that catalyzes removal of methyl groups using alpha-ketoglutarate as a cofactor. It demethylates H3K36me3 and is implicated in the demethylation of H3K9me3 and H3K56me3. Its roles include transcription, DNA repair, and heterochromatin silencing.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR10694
No data available
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Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
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Annotation details
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    Disease Associations

    Cases where the expected disease association was NOT found
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      Alleles and Variants

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        Transgenic Alleles

        Species
        (carrying the transgene)
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          Models

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            Sequence Feature Viewer

            Genome location
            Assembly version
            R6
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            7.9228M7.9230M7.9232M7.9234M7.9236M7.9238M7.9240M7.9242M7.9244M7.9246M7.9248M

            Sequence Details

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            Expression

            Primary Sources
            Other Sources
            Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

            Molecular Interactions

            Kdm4A molecule type
            Interactor gene
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              Genetic Interactions

              Kdm4A role
              Kdm4A genetic perturbation
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