Enables ubiquitin ligase complex scaffold activity. Involved in several processes, including chaeta morphogenesis; eggshell chorion gene amplification; and regulation of signal transduction. Located in nucleus. Part of Cul4-RING E3 ubiquitin ligase complex. Human ortholog(s) of this gene implicated in syndromic X-linked intellectual disability Cabezas type. Orthologous to several human genes including CUL4A (cullin 4A).
FB Description
Cullin 4 (Cul4) encodes the molecular scaffold for the CRL4 E3 ubiquitin ligase complex, which catalyzes the ubiquitylation and subsequent destruction of proteins that function in cell growth and proliferation as well as transcription, replication and repair of the genome.