Version: 8.0.0
Date: Tue Jan 28 2025
Socs44A
Drosophila melanogasterFB:FBgn0033266
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

Socs44A

Species
Drosophila melanogaster
Symbol
Socs44A
Name
Suppressor of Cytokine Signaling at 44A
Synonyms
  • CG2160
  • dmSocs44A
Biotype
protein coding gene
Automated Description
Predicted to enable signaling adaptor activity. Involved in negative regulation of receptor signaling pathway via JAK-STAT and positive regulation of epidermal growth factor receptor signaling pathway. Is expressed in several structures, including embryonic/larval midgut; embryonic/larval midgut primordium; embryonic/larval tracheal section; and oocyte. Human ortholog(s) of this gene implicated in several diseases, including acute myeloid leukemia; gastrointestinal system cancer (multiple); malaria; obesity; and reproductive organ cancer (multiple). Orthologous to several human genes including CISH (cytokine inducible SH2 containing protein); SOCS1 (suppressor of cytokine signaling 1); and SOCS2 (suppressor of cytokine signaling 2).
FB Description
Suppressor of Cytokine Signaling at 44A (Socs44A) encodes a protein that promotes the degradation of interacting proteins by recruiting Cullin/Elongin ubiquitin ligase complexes. It activity negatively regulates JAK/STAT signaling and positively impacts RTK signaling in a context specific manner, which can impact developmental patterning.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR10155
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
Phenotype Term
Annotation details
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume
    No data available

    Alleles and Variants

    Allele/Variant Symbol
    Allele Synonyms
    Category
    Variant
    Variant type
    Molecular consequence
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      Transgenic Alleles

      Species
      (carrying the transgene)
      Allele symbol
      Transgenic construct
      Expressed components
      Knock-down targets
      Regulatory regions
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      Has Phenotype Annotations
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        Models

        Model name
        Experimental condition
        Associated Human Diseases
        Associated Phenotypes
        Modifier
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          Sequence Feature Viewer

          Genome location
          Assembly version
          R6
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          Data currently unavailable; sequence viewer under construction

          Sequence Details

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          Expression

          Primary Sources
          Other Sources
          Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

          Molecular Interactions

          Socs44A molecule type
          Interactor gene
          Interactor species
          Interactor molecule type
          Detection methods
          Source
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            Genetic Interactions

            Socs44A role
            Socs44A genetic perturbation
            Interactor gene
            Interactor species
            Interactor role
            Interactor genetic perturbation
            Interaction type
            Phenotype or trait
            Source
            Reference
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