Gene

nopo

Species
Drosophila melanogaster
Symbol
nopo
Name
no poles
Synonyms
  • CG5140
  • Nopo
Biotype
protein coding gene
Automated Description
Enables DNA polymerase binding activity and ubiquitin conjugating enzyme binding activity. Involved in several processes, including lysosomal protein catabolic process; positive regulation of mitotic cell cycle, embryonic; and positive regulation of tumor necrosis factor-mediated signaling pathway. Located in nucleus. Is expressed in organism. Used to study Seckel syndrome 9. Human ortholog(s) of this gene implicated in Seckel syndrome 9. Orthologous to human TRAIP (TRAF interacting protein).
FB Description
no poles (nopo) encodes a RING domain-containing E3 ubiquitin ligase that is essential for early embryogenesis. It positively regulates caspase-dependent cell death.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR46569
No data available
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
Phenotype Term
Annotation details
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume
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      Alleles and Variants

      Allele/Variant Symbol
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      Variant
      Variant type
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        Transgenic Alleles

        Species
        (carrying the transgene)
        Allele symbol
        Transgenic construct
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        Knock-down targets
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          Models

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            Sequence Feature Viewer

            Genome location
            Assembly version
            R6
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            18.1806M18.1808M18.1810M18.1812M18.1814M18.1816M18.1818M18.1820M18.1822M18.1824M

            Sequence Details

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            Expression

            Primary Sources
            Other Sources
            Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

            Molecular Interactions

            nopo molecule type
            Interactor gene
            Interactor species
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              Genetic Interactions

              nopo role
              nopo genetic perturbation
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