Version: 8.0.0
Date: Tue Jan 28 2025
Asciz
Drosophila melanogasterFB:FBgn0035407
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

Asciz

Species
Drosophila melanogaster
Symbol
Asciz
Name
ASCIZ zinc finger protein
Synonyms
  • ASCIZ
  • ASCIZ homolog
Biotype
protein coding gene
Automated Description
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and transcription cis-regulatory region binding activity. Involved in metamorphosis; positive regulation of transcription by RNA polymerase II; and regulation of mitotic nuclear division. Located in nucleus; polytene chromosome; and spindle matrix. Is expressed in several structures, including central brain anlage; central brain anlage in statu nascendi; central brain primordium; clypeo-labral primordium; and embryonic brain. Orthologous to human ATMIN (ATM interactor).
FB Description
ASCIZ zinc finger protein (Asciz) encodes a transcription factor that regulates the expression of ctp, which encodes a LC8 dynein light chain. The product of Asciz is involved in dynein motor functions, including mitotic chromosome segregation, and dynein-independent functions, such as patterning of cell cycles and apoptosis during development.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR46664
No data available
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
Phenotype Term
Annotation details
References
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume
    Gene
    Association
    Disease Qualifier
    Disease
    Evidence
    Source
    Based On
    References
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      Alleles and Variants

      Allele/Variant Symbol
      Allele Synonyms
      Category
      Variant
      Variant type
      Molecular consequence
      Has Disease Annotations
      Has Phenotype Annotations
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        Transgenic Alleles

        Species
        (carrying the transgene)
        Allele symbol
        Transgenic construct
        Expressed components
        Knock-down targets
        Regulatory regions
        Has Disease Annotations
        Has Phenotype Annotations
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          Models

          Model name
          Experimental condition
          Associated Human Diseases
          Associated Phenotypes
          Modifier
          Source
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            Sequence Feature Viewer

            Genome location
            Assembly version
            R6
            Viewer Help
            3.1638M3.1640M3.1642M3.1644M3.1646M3.1648M3.1650M3.1652M3.1654M3.1656M3.1658M3.1660M3.1662M

            Sequence Details

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            Expression

            Primary Sources
            Other Sources
            Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

            Molecular Interactions

            Asciz molecule type
            Interactor gene
            Interactor species
            Interactor molecule type
            Detection methods
            Source
            Reference
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              Genetic Interactions

              Asciz role
              Asciz genetic perturbation
              Interactor gene
              Interactor species
              Interactor role
              Interactor genetic perturbation
              Interaction type
              Phenotype or trait
              Source
              Reference
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