Gene

Ppat-Dpck

Species
Drosophila melanogaster
Symbol
Ppat-Dpck
Name
Bifunctional Phosphopantetheine adenylyltransferase - Dephospho-CoA kinase
Synonyms
  • 4'-phosphopantetheine adenylyltransferase - dephospho-CoA kinase
  • CG10575
Biotype
protein coding gene
Automated Description
Predicted to enable dephospho-CoA kinase activity and pantetheine-phosphate adenylyltransferase activity. Involved in triglyceride homeostasis. Predicted to be located in mitochondrion. Is expressed in adult head. Used to study neurodegeneration with brain iron accumulation 6. Human ortholog(s) of this gene implicated in mucopolysaccharidosis III; neurodegeneration with brain iron accumulation 6; and pontocerebellar hypoplasia type 12. Orthologous to human COASY (Coenzyme A synthase).
FB Description
Bifunctional Phosphopantetheine adenylyltransferase - Dephospho-CoA kinase (Ppat-Dpck) encodes a bifunctional enzyme that carries out the last two steps of the canonical Coenzyme A (CoA) biosynthesis pathway. The Ppat part converts 4'-phosphopantetheine into dephospho-CoA and subsequently the Dpck part phosphorylates dephospho-CoA to form CoA.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR10695
No data available
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Paralogy

Function - GO Annotations

Pathways

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Phenotypes

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    Disease Associations

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      Alleles and Variants

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        Transgenic Alleles

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        (carrying the transgene)
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          Models

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            Sequence Feature Viewer

            Genome location
            Assembly version
            R6
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            5.7672M5.7674M5.7676M5.7678M5.7680M5.7682M5.7684M5.7686M

            Sequence Details

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            Expression

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            Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

            Molecular Interactions

            Ppat-Dpck molecule type
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              Genetic Interactions

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