Version: 8.0.0
Date: Tue Jan 28 2025
Ppat-Dpck
Drosophila melanogasterFB:FBgn0035632
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

Ppat-Dpck

Species
Drosophila melanogaster
Symbol
Ppat-Dpck
Name
Bifunctional Phosphopantetheine adenylyltransferase - Dephospho-CoA kinase
Synonyms
  • 4'-phosphopantetheine adenylyltransferase - dephospho-CoA kinase
  • CG10575
Biotype
protein coding gene
Automated Description
Predicted to enable dephospho-CoA kinase activity and pantetheine-phosphate adenylyltransferase activity. Involved in triglyceride homeostasis. Predicted to be located in mitochondrion. Is expressed in adult head. Used to study neurodegeneration with brain iron accumulation 6. Human ortholog(s) of this gene implicated in mucopolysaccharidosis III; neurodegeneration with brain iron accumulation 6; and pontocerebellar hypoplasia type 12. Orthologous to human COASY (Coenzyme A synthase).
FB Description
Bifunctional Phosphopantetheine adenylyltransferase - Dephospho-CoA kinase (Ppat-Dpck) encodes a bifunctional enzyme that carries out the last two steps of the canonical Coenzyme A (CoA) biosynthesis pathway. The Ppat part converts 4'-phosphopantetheine into dephospho-CoA and subsequently the Dpck part phosphorylates dephospho-CoA to form CoA.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR10695
No data available
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Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

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Other Sources
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Annotation details
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    Disease Associations

    Cases where the expected disease association was NOT found
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      Alleles and Variants

      Allele/Variant Symbol
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        Transgenic Alleles

        Species
        (carrying the transgene)
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          Models

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            Sequence Feature Viewer

            Genome location
            Assembly version
            R6
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            5.7672M5.7674M5.7676M5.7678M5.7680M5.7682M5.7684M5.7686M

            Sequence Details

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            Expression

            Primary Sources
            Other Sources
            Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

            Molecular Interactions

            Ppat-Dpck molecule type
            Interactor gene
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              Genetic Interactions

              Ppat-Dpck role
              Ppat-Dpck genetic perturbation
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