Gene

tow

Species
Drosophila melanogaster
Symbol
tow
Name
target of wingless
Synonyms
  • CG14821
  • Target of Wingless
Biotype
protein coding gene
Automated Description
Involved in establishment of planar polarity; imaginal disc-derived wing hair organization; and negative regulation of smoothened signaling pathway. Located in nucleus. Is expressed in several structures, including adult head; ganglia; larval nervous system; and wing disc. Orthologous to human C1orf21 (chromosome 1 open reading frame 21).
FB Description
target of wingless (tow) overexpression and genetic interaction studies suggest that it acts downstream of the products of fz/dsh (Planar Cell Polarity pathway) and upstream of the product of smo (Hedgehog pathway) during development.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR14974
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
R6
Viewer Help
6.943M6.944M6.945M6.946M6.947M6.948M6.949M

Sequence Details

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Expression

Primary Sources
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions