Involved in establishment of planar polarity; imaginal disc-derived wing hair organization; and negative regulation of smoothened signaling pathway. Located in nucleus. Is expressed in several structures, including adult head; ganglia; larval nervous system; and wing disc. Orthologous to human C1orf21 (chromosome 1 open reading frame 21).
FB Description
target of wingless (tow) overexpression and genetic interaction studies suggest that it acts downstream of the products of fz/dsh (Planar Cell Polarity pathway) and upstream of the product of smo (Hedgehog pathway) during development.