Gene

CTCF

Species
Drosophila melanogaster
Symbol
CTCF
Name
CTCF
Synonyms
  • CCCTC-binding factor
  • CCCTC-Binding Factor
Biotype
protein coding gene
Automated Description
Enables chromatin insulator sequence binding activity and transcription cis-regulatory region binding activity. Involved in several processes, including maintenance of rDNA; regulation of gene expression; and response to ecdysone. Located in nucleus. Is expressed in central brain primordium; embryonic brain; larval ventral nerve cord; organism; and ventral nerve cord primordium. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder 21; basal cell carcinoma; female breast cancer; skin melanoma; and skin squamous cell carcinoma. Orthologous to human CTCF (CCCTC-binding factor) and CTCFL (CCCTC-binding factor like).
FB Description
CTCF (CTCF) encodes a ubiquitous transcription factor that binds to insulators and domain boundaries. It mediates insulator function and blocks enhancers by binding to the product of Cp190. It contributes to long-range chromatin interaction, organizes chromatin domain boundaries and coordinates nuclear architecture.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR24390
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
R6
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7.3540M7.3545M7.3550M7.3555M7.3560M7.3565M

Sequence Details

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Expression

Primary Sources
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions