Gene

nst

Species
Drosophila melanogaster
Symbol
nst
Name
nesthocker
Synonyms
  • CG10627
  • DPgm3
Biotype
protein coding gene
Automated Description
Predicted to enable phosphoacetylglucosamine mutase activity. Involved in several processes, including UDP-N-acetylglucosamine biosynthetic process; positive regulation of fibroblast growth factor receptor signaling pathway; and trachea development. Predicted to be located in cytoplasm. Is expressed in several structures, including adult head; embryonic/larval midgut primordium; epithelium; gut section; and trunk visceral muscle primordium. Human ortholog(s) of this gene implicated in immunodeficiency 23 and teratoma. Orthologous to human PGM3 (phosphoglucomutase 3).
FB Description
nesthocker (nst) encodes a phospho-acetylglucosamine mutase, an essential enzyme in the biosynthetic pathway of N-Acetylglucosamine (GlcNAc). In the embryo, it is required for normal GlcNAc levels and affects Fibroblast-Growth-Factor signaling.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR45955
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
R6
Viewer Help
12.5275M12.5280M12.5285M12.5290M12.5295M12.5300M

Sequence Details

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Expression

Primary Sources
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions