Predicted to enable phosphoacetylglucosamine mutase activity. Involved in several processes, including UDP-N-acetylglucosamine biosynthetic process; positive regulation of fibroblast growth factor receptor signaling pathway; and trachea development. Predicted to be located in cytoplasm. Is expressed in several structures, including adult head; embryonic/larval midgut primordium; epithelium; gut section; and trunk visceral muscle primordium. Human ortholog(s) of this gene implicated in immunodeficiency 23 and teratoma. Orthologous to human PGM3 (phosphoglucomutase 3).
FB Description
nesthocker (nst) encodes a phospho-acetylglucosamine mutase, an essential enzyme in the biosynthetic pathway of N-Acetylglucosamine (GlcNAc). In the embryo, it is required for normal GlcNAc levels and affects Fibroblast-Growth-Factor signaling.